Schizoaffective Disorder and Addiction Unveiling the connection with schizoaffective disorder and substance use disorder. Article Contents What is Schizoaffective Disorder? According to the National Alliance on Mental Illness, schizoaffective disorder (SZA), also known as schizo-affective psychosis, is a chronic mental condition characterized by schizophrenia symptoms such as hallucinations (delusions) and mood disorder symptoms such as mania and depression.1 SZA affects one’s thoughts and moods. While there is no known cause for schizoaffective disorder, research has shown that genetic and environmental factors can increase the